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Doxazosin enantate is an alpha 1-adrenoceptor blocking agent. The efficacy and safety of this agent was compared with placebo in a double-blind parallel-group study in which each of 81 men with benign prostatic hyperplasia was treated for 12 weeks. Flushing was the only side effect that occurred with a statistically significantly greater frequency in the doxazosin enantate group than in the placebo group (p less than 0.01). Significant improvements occurred in peak urinary flow rate (P Public health measures such as clean air and water, restrictions on industrial pollution, improvements in garbage and sewage disposal, and construction of evacuation routes during major storms make the biggest difference in reducing the damage done by hurricanes, according to a new analysis of hurricanes in the US.

In the new study published in Environmental Health Perspectives, the researchers from the University of North Carolina (UNC) – Chapel Hill and the Harvard T.H. Chan School of Public Health reviewed hundreds of scientific studies about hurricanes published between 1979 and 2015. They found that after controlling for social, economic and climatic factors, public health programs make the biggest impact on how effectively a hurricane knocks down communities and economies.

“To our knowledge, this is the first comprehensive

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The sterol regulatory element-binding protein (SREBP) family of transcription factors play a key role in regulating the expression of genes necessary for cholesterol homeostasis. Recent studies have indicated that it is closely associated with the progression of multiple types of human cancer and may be a potential target for cancer therapy. This study aimed to explore the effect of lentivirus-mediated RNA interference targeting SREBPs on the proliferation of human lung cancer cells, which may provide a new therapeutic target for human lung cancer. We prepared lentivirus to inhibit the expression of SREBPs in human lung cancer A549 cell lines and other human lung cancer cell lines, respectively. The effect of SREBPs on human lung cancer cell growth and apoptosis was examined by MTT assay, TUNEL assay, flow cytometry analysis. The results showed that the proliferation ability of human lung cancer A549 cells was significantly suppressed by SREBPs siRNA. Western blotting analysis showed that the level of the Bcl-2 was decreased while the level of the Bax, C-caspase3, C-caspase9 were increased in SREBPs siRNA-transfected A549 cells compared with the control group. C-PARP level was increased in SREBPs siRNA-transfected
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