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The quantitative characteristics of the regulatory processes of protein synthesis in the liver of hibernating ground squirrels have been studied. It has been shown that the anabolic processes become more intensive and the catabolic processes weaker during the first 6 months of hibernation period. The elevated activity of the regulatory mechanism is due to an increase in the total concentration of the factor of the feedback control of protein synthesis, i.e. of the poly-ribosomes and the precursor nucleosides in the liver of hibernating animals. The activity of the regulatory mechanism also increases due to the decreased activity of the RNase-ligase enzyme, while the enzyme of the amino acid decomposition increases with the development of the hibernating state. The activity of the regulatory mechanism decreases due to the denaturation of the translation protein and the ribonucleases of some bacterial origin in the liver. The content of precursors of the regulatory process shows the opposite relation to that of the total concentration of the factor of the feedback control of protein synthesis. The positive correlation observed between the concentration of the factor of the feedback control of protein synthesis and the total concentration of the precursors in the liver suggests a correlation between them. At the same time, the total concentration of the precursors in the liver decreases with the development of hibernation. The decrease in the total concentration of the precursors of the regulatory process reflects in turn, due to the activation of the catabolic processes, the general breakdown of the protein synthesis.Mito Sukezane
was a Japanese daimyō of the early Edo period, ruling the Edo Castle domain.
Mito Sukezane was the son of Mito Terumoto and was born either in February or March 1654, or 1656. Because the Mito Terumoto died in 1657 or 1658, it is possible that Mito Sukezane was born in the year of 1658. He was born in Katsura (modern-day Kawasaki, Kanagawa Prefecture) in the province of Musashi, but his childhood home was at Tado no juku, Edo Castle. His childhood home was a room in the east wing (the Se
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Optimal management of patients with cerebral peduncular infarction (CPI) is still challenging. Review of the clinical presentations and outcome of patients with CPI. An Internet search using the terms “cerebral peduncular infarction,” “central pontine myelinolysis,” and “lateral medullary syndrome” was performed. Studies that described cerebrospinal fluid (CSF) and plasma levels of neurofilament light chain protein (NfL) were also identified. Clinical features of CPI are variable. Patients usually present with limb weakness and dysphagia. Cranial nerve deficits are less common. A combination of dysphagia and gait/coordination changes should alert the clinician to an underlying CPI. Headache and altered mental status should raise suspicion of central pontine myelinolysis. Results of blood tests including NfL levels are usually normal. CSF NfL levels are higher in patients with central pontine myelinolysis. Acute CPI is often a single infarction, whereas patients with partial infarcts on diffusion-weighted imaging and magnetic resonance imaging should be treated as having a chronic CPI. Misdiagnosis of CPI leads to inappropriate treatment and increased morbidity.using LibVLCSharp.Forms.EventArgs;
public class SourcePlayerControl : PlayerControl
private readonly Func _media;